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Medchemexpress LLC AG-636 | 1623416-31-8 | 98.1% | 343.38 | 5 MG
Supplier: Medchemexpress LLC 5MGHY137463
AG-636 is a potent, reversible, selective, and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. It demonstrates strong anticancer effects.
- Exhibits strong growth-inhibitory activity in cancer cell lines of both hematologic and solid tumor origin.
- Functions as a dihydroorotate dehydrogenase (DHODH) inhibitor.
- Applications:
- In vitro: has shown strong growth-inhibitory activity in various cancer cell lines.
- In vivo: treatment resulted in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model.
- Clinical trials: being investigated in a Phase 1 clinical trial (NCT03834584) for lymphoma, which started on May 24, 2019.
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