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Medchemexpress LLC AGI-41998 | 2377492-26-5 | 99.94% | C22H16BrF3N4O2 | 50 MG
SDP

Catalog No. 5000355212
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AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It shows inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM respectively. AGI-41998 significantly inhibits the proliferation of HCT-116 cells and tumor growth, and can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer.

  • Potent and orally active inhibitor of MAT2A
  • Effectively penetrates the blood-brain barrier
  • Exhibits inhibitory activities against MAT2A and SAM in HCT-116 MTAP-null cells
  • Significantly inhibits proliferation of HCT-116 cells and tumor growth
  • Can be used for research on SAM regulation in the CNS and colon cancer

Catalog No. 50-003-55212 Supplier Medchemexpress LLC Supplier No. HY14577850MG
May include imposed supplier surcharges.
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AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It shows inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM respectively. AGI-41998 significantly inhibits the proliferation of HCT-116 cells and tumor growth, and can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer.

  • Potent and orally active inhibitor of MAT2A
  • Effectively penetrates the blood-brain barrier
  • Exhibits inhibitory activities against MAT2A and SAM in HCT-116 MTAP-null cells
  • Significantly inhibits proliferation of HCT-116 cells and tumor growth
  • Can be used for research on SAM regulation in the CNS and colon cancer

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