Medchemexpress LLC AGI-43192 | 2377491-54-6 | 99.5% | C23H16ClF3N6O | 1 ML

Supplier:  Medchemexpress LLC HY14577710MM/1ML

AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that limitedly penetrates the blood-brain barrier. It exhibits inhibitory activity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 32 and 14 nM, respectively. It can significantly inhibit the proliferation of HCT-116 cells and tumor growth, making it useful for studying SAM regulation in the central nervous system (CNS) and colon cancer.

• Potent, orally active MAT2A inhibitor.
• Limited blood-brain barrier penetration.
• Inhibits MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells.
• Significantly inhibits HCT-116 cell proliferation and tumor growth.
• Exhibits antiproliferative activity against HCT-116 cell lines (GI50s of 19 and 173 nM).
• Reduces tumor and brain SAM levels in mice.
• Soluble in DMSO (13.89 mg/mL).

Catalog No. 50-003-54012