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Medchemexpress LLC AGI-5198 | 1355326-35-0 | 99.9% | 462.56 | 5 MG
Supplier: Medchemexpress LLC HY180825MG
AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM. It causes 50 to 60% growth inhibition of human glioma xenografts and does not affect the growth of IDH1 wild-type glioma xenografts. This compound reverses the effects of ionizing radiation (IR) on IDH1(R132H) mutated cancer cells, leading to higher levels of reactive oxygen species, DNA double-strand breaks, and cell death.
- Potent and selective mutant IDH1R132H inhibitor.
- Causes 50 to 60% growth inhibition of human glioma xenografts.
- Does not affect the growth of IDH1 wild-type glioma xenografts.
- Reverses the effects of ionizing radiation (IR) on IDH1(R132H) mutated cancer cells, leading to higher levels of reactive oxygen species, DNA double-strand breaks, and cell death.
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