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Medchemexpress LLC AGI-5198 | 1355326-35-0 | 99.9% | 462.56 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1808250MG

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AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM. It is designed for research use only.

  • Potent and selective mutant IDH1R132H inhibitor.
  • Inhibits mutant IDH1 enzyme in TS603 glioma cells.
  • Does not impair colony formation of wild-type IDH1 glioma lines.
  • Reverses increased reactive oxygen species, DNA double-strand breaks, and cell death after ionizing radiation in IDH1(R132H) mutated cancer cells.
  • Causes significant growth inhibition of human glioma xenografts in vivo.

Catalog No. 50-003-87244


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