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Cayman Chemical AIF Blockng PeptIde 1ea
Supplier: Cayman Chemical 3607731 EA
A peptide fragment of ApoE and an a7 nAChR antagonist (IC50 720 nM) suppresses TNF-a and NO release in BV-2 microglia from 10-50 UM reduces LPS-induced increases in brain levels of TNF-a and IL-6 in mice decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact at 203 and 406 Ug/kg delays disease onset and reduces disease severity in a mouse model of EAE at 1 mg/kg
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