ProSci AIFM2 (CT) Peptide

Catalog No.	Quantity
16-595-427	0.05 mg

Catalog No. 16-595-427 Supplier ProSci Supplier No. 9653P0050

Description

Used for Blocking Activity

AIFM2 (CT) Peptideis used for blocking the activity of theAIFM2 (CT) Antibody

AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis

Specifications

• Gene ID (Entrez): 84883
• Species: Human
• Accession Number: Q9BRQ8
• Common Name: apoptosis inducing factor mitochondria associated
• Concentration: 200 μg/mL
• Content And Storage: Store AIFM2 (CT) Peptide at -20°C, stable for one year.
• Format: Liquid
• Formulation: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• For Use With (Application): Blocking Assay
• Gene Symbol: AIMF2
• Quantity: 0.05 mg
• Sequence: 12 amino acids near the carboxy terminus of AIFM2 (CT).
• Synonym: AIMF2