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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 1 ML
Supplier: Medchemexpress LLC HY14470710MM/1ML
AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. The compound acts by inhibiting the ID2-KDR signaling axis, leading to the down-regulation of angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and the up-regulation of the tumor suppressor factor (PTEN). It is suitable for the study of glioma.
- Potent ID2 antagonist with a KD of 129 nM
- Inhibits cell migration and invasion in glioma cell lines
- Induces apoptosis
- Exhibits significant cancer-suppressing potency
- Down-regulates angiogenic factors (VEGFA)
- Down-regulates invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Inhibits tumor growth in U87 glioma xenograft mice model
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