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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14470750MG

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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM, used for the study of glioma. It inhibits the ID2-KDR signaling axis, leading to the downregulation of downstream angiogenic factors and invasion-related proteins, and the upregulation of the tumor suppressor factor PTEN. This compound demonstrates significant cancer-suppressing potency by inhibiting cell migration and invasion of glioma cell lines and inducing apoptosis.

  • Potent ID2 antagonist with a KD of 129 nM
  • Inhibits cell migration and invasion of glioma cell lines
  • Induces apoptosis
  • Inhibits ID2-KDR signaling axis
  • Downregulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
  • Upregulates tumor suppressor factor (PTEN)

Catalog No. 50-003-55845


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