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Medchemexpress LLC Akn-028 (acetate) | 98.38% | 362.39 | 100 MG
Supplier: Medchemexpress LLC HY118304B100MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor. It is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 acetate induces apoptosis by activation of caspase 3 and can be used in research of acute myeloid leukemia (AML).
- Potent and orally active FLT3 inhibitor with an IC50 of 6 nM.
- Inhibits FLT3 autophosphorylation.
- Induces dose-dependent cytotoxic response with a mean IC50 of 1 μM.
- Induces apoptosis through activation of caspase 3.
- Suitable for research in acute myeloid leukemia (AML).
- Shows cytotoxic activity against AML cell lines.
- Inhibits tumor growth in xenograft models.
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