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Medchemexpress LLC AKN-028 (acetate) | 98.4% | 362.39 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY118304B10MG

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AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor and a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation, induces dose-dependent cytotoxic response (mean IC50=1 μM), and triggers apoptosis by activating caspase 3. This compound is used in research of acute myeloid leukemia (AML).

  • Potent, orally active FLT3 inhibitor (IC50 value of 6 nM)
  • Inhibits FLT3 and KIT autophosphorylation
  • Induces dose-dependent cytotoxic response (mean IC50=1 μM)
  • Triggers apoptosis by activating caspase 3
  • Effective in research models of acute myeloid leukemia (AML)
  • Exhibits cytotoxic activity against AML cell lines
  • Targets multiple kinases including CLK1, RPS6KA, VEGFR2, and FGFR2

Catalog No. 50-004-35724


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