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Medchemexpress LLC AKN-028 acetate | 98.4% | 362.39 | 50 MG
Supplier: Medchemexpress LLC HY118304B50MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor. It is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response (mean IC50=1 μM). It also induces apoptosis by activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
- Novel tyrosine kinase (TK) inhibitor
- Potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM
- Inhibits FLT3 autophosphorylation
- Induces a dose-dependent cytotoxic response (mean IC50=1 μM)
- Induces apoptosis by activation of caspase 3
- Can be used in research of acute myeloid leukemia (AML)
- Inhibits growth of primary AML and MV4-11 cells in mice
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