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Echelon Biosciences Research LabsSupplier Diversity Partner AKT INHIBITOR (KP372-1) 5 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B01025MG

KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. Provided as a 1:1 mixture of regioisomers.\n\n



\nWater: insoluble, DMSO: 5 mg/mL\n


\n2-8oC. Stock solutions should be stored frozen (-20oC).\n


\n1) M.

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