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Echelon Biosciences Research Labs AKT INHIBITOR (KP372-1) 5 mg
SDP

Supplier:  Echelon Biosciences Research Labs B01025MG

Encompass

KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. Provided as a 1:1 mixture of regioisomers.nn

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Solubility

nWater: insoluble, DMSO: 5 mg/mLn

Storage

n2-8oC. Stock solutions should be stored frozen (-20oC).n

References

n1) M. This item is non returnable

Catalog No. 50-720-007


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