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STEMCELL Technologies AKT Inhibitor VIII, Size: 10 mg
SDP

Supplier:  STEMCELL Technologies 72944

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AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC₅₀ values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.). It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.).   CANCER RESEARCH· Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.).· Blocks mitosis and inhibits migration of HeLa cells (Jo et al.). METABOLISM· Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.).

Catalog No. 50-197-6004


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