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STEMCELL Technologies AKT Inhibitor X (Hydrochloride), Size: 10 mg
Supplier: STEMCELL Technologies 72952
AKT Inhibitor X is a cell-permeable phenoxazine-derivative inhibitor of AKT kinase phosphorylation with an IC₅₀ of ~1 - 2 μM. AKT Inhibitor X blocks translocation of AKT after insulin-like growth factor 1 (IGF-1) treatment (Thimmaiah et al.). This product is supplied as the hydrochloride salt of the molecule.CANCER RESEARCH· Inhibits growth and induces apoptosis of human rhabdomyosarcoma cell lines (Thimmaiah et al.).· Inhibits proliferation of breast cancer cell lines, alone or synergistically with chloroquine (Hu et al.).· Reduces replication of Myxoma virus in a variety of human tumor cell lines (Werden & McFadden). DISEASE MODELING· Induces autophagy in neurons and is neuroprotective in a primary neuronal Huntington Disease cellular model (Tsvetkov et al.).
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WARNING: Cancer - www.P65Warnings.ca.gov
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