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Cayman Chemical AldoxorubIcInhydrochLRIde 10mg
Supplier: Cayman Chemical 3531110 MG
A prodrug form of doxorubicin; selectively binds to serum albumin, which releases doxorubicin in acidic environments, such as the tumor microenvironment; inhibits the proliferation of RenCa, MCF-7, and LXFL 529 cells (IC50s = 1, 1.1, and 0.5 µM, respectively); induces tumor regression in an MDA-MB-435 breast cancer mouse xenograft model at 39.3 µmol/kg; not toxic to mice unlike doxorubicin (LD50 = >60 mg/kg); has been used to conjugate doxorubicin to antibodies
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