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Apexbio Technology LLC Alendronate sodium(Synonyms: Alendronate sodium hydrate, Sodium alendronate, Alendronic acid monosodium salt, Fosamax), 10mM (in 1mL DMSO), CAS: 129318-43-0.
Supplier: Apexbio Technology LLC A83595.1
Alendronate sodium (CAS 129318-43-0) is a small molecule inhibitor of osteoclast-driven bone resorption It acts by selectively inhibiting farnesyl diphosphate synthase (FPPS) an essential enzyme within the mevalonate (HMG-CoA reductase) pathway exhibiting an IC50 of approximately 460 nM against recombinant human FPPS Inhibition of FPPS prevents protein prenylation and sterol biosynthesis within osteoclasts subsequently inducing apoptosis in macrophage-lineage cells Alendronate sodium is commonly utilized in biomedical research focused on bone metabolism disorders osteoclast biology and evaluation of therapeutic strategies targeting bone density loss
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