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Apexbio Technology LLC Alfacalcidol 41294-56-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21535.1
Alfacalcidol is a vitamin D analog functioning as an inhibitor of bone resorption through modulation of calcium homeostasis By binding specifically to vitamin D receptors (VDR) located in calcium-regulating tissues such as intestine bone kidney and parathyroid glands Alfacalcidol contributes to mineral metabolism and bone turnover regulation Preclinical studies using ovariectomized animal models demonstrate that Alfacalcidol at pharmacological doses not inducing hypercalcemia suppresses osteoclast-mediated bone resorption while preserving calcium balance in plasma and urine Due to these properties Alfacalcidol is frequently utilized in biomedical research to investigate mechanisms involved in osteoporosis progression and potential therapeutic interventions addressing calcium and bone metabolism disorders
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