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Eurofins Discoverx ALK2, active, 250 µg. (14-937M)
Supplier: Eurofins Discoverx 14937M
N-terminal 6xHis-tagged recombinant, human ALK2 amino acids 147-end. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor (TGF)-beta superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. For detailed product information, visit www.discoverx.com/proteins.
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