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Enzo Life Sciences ALK5 Inhibitor I (5mg). CAS: 396129-53-6
SDP

Supplier:  Enzo Life Sciences ALX270448M005

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Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Alternative name: TGF-beta RI Kinase Inhibitor I, 3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole. Purity: ≥97% (1H-NMR). Appearance: Yellow to brown solid. Solubility: Soluble in DMSO or methanol. Long Term Storage: -20°C.

Catalog No. 50-200-8573


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