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Biotium Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker)(ALPP/516), CF740 conjugate, 0.1mg/mL
Supplier: Biotium BNC740516500
This antibody reacts with placental alkaline phosphatase. There are at least four distinct but related alkaline phosphatases: intestinal, placental (PLAP), placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. PLAP is a tissue specific, trophoblast-derived, 70 kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, zinc metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific AP's in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some
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