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Medchemexpress LLC Allo-aca | 99.82% | 1074.19 | 5 MG
SDP

Catalog No. 5000398835
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Allo-aca is a leptin peptidomimetic, acting as a potent and specific leptin receptor antagonist peptide. It effectively blocks leptin signaling and action across various in vitro and in vivo models, demonstrating significant biological activity in cellular and animal studies.

  • Inhibits leptin-induced proliferation in MDA-MB-231 cells at 50 pM.
  • Inhibits leptin-induced proliferation in MCF-7 cells with an IC50 of 200 pM.
  • Reduces VEGF-dependent leptin mRNA expression.
  • Inhibits VEGF mitogenic effects.
  • Inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells.
  • Significantly extends average survival time in an MDA-MB-231 orthotopic mouse xenograft model with subcutaneous administration.

Catalog No. 50-003-98835 Supplier Medchemexpress LLC Supplier No. HYP32125MG
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Allo-aca is a leptin peptidomimetic, acting as a potent and specific leptin receptor antagonist peptide. It effectively blocks leptin signaling and action across various in vitro and in vivo models, demonstrating significant biological activity in cellular and animal studies.

  • Inhibits leptin-induced proliferation in MDA-MB-231 cells at 50 pM.
  • Inhibits leptin-induced proliferation in MCF-7 cells with an IC50 of 200 pM.
  • Reduces VEGF-dependent leptin mRNA expression.
  • Inhibits VEGF mitogenic effects.
  • Inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells.
  • Significantly extends average survival time in an MDA-MB-231 orthotopic mouse xenograft model with subcutaneous administration.

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