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Medchemexpress LLC Almonertinib hydrochloride | 2134096-03-8 | 98.9% | 562.11 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY112823B100MG

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Almonertinib hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. It shows significant inhibitory activity against T790M, T790M/L858R, and T790M/Del19 (IC50: 0.37, 0.29, and 0.21 nM, respectively) and is less effective against wild type (3.39 nM). It is used for the research of non-small cell lung cancer.

  • Orally available
  • Irreversible
  • Third-generation EGFR tyrosine kinase inhibitor
  • High selectivity for EGFR-sensitizing and T790M resistance mutations
  • Significant inhibitory activity against T790M, T790M/L858R, and T790M/Del19
  • Effective against other EGFR sensitive mutations including G719X, del19, L858R, and L861Q

Catalog No. 50-004-37754


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