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Medchemexpress LLC Almonertinib (hydrochloride) | 2134096-03-8 | 98.9% | 562.11 | 50 MG
Supplier: Medchemexpress LLC HY112823B50MG
Almonertinib hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It exhibits high selectivity for EGFR-sensitizing and T790M resistance mutations and is utilized in non-small cell lung cancer research. It can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Potent inhibitory activity against T790M (IC50: 0.37 nM), T790M/L858R (IC50: 0.29 nM), and T790M/Del19 (IC50: 0.21 nM)
- Less effective against wild-type EGFR (IC50: 3.39 nM)
- Used for research in non-small cell lung cancer (NSCLC)
- Inhibits other EGFR sensitive mutations such as G719X, del19, L858R, and L861Q
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