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Medchemexpress LLC Alogliptin Benzoate (SYR 322) | 850649-62-6 | 100.0% | C25H27N5O4 | 200 MG
SDP

Supplier:  Medchemexpress LLC HYA0023200MG

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Alogliptin Benzoate (SYR-322) is a potent, selective, and orally active inhibitor of DPP-4 with an IC50 of <10 nM, exhibiting over 10,000-fold selectivity over DPP-8 and DPP-9. It is suitable for research into type 2 diabetes.

  • Potent, selective, and orally active inhibitor of DPP-4.
  • Inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells.
  • Inhibits LPS-stimulated MMP-1 secretion and mRNA expression mediated by the ERK pathway in U937 cells.
  • Improves glucose tolerance and increases plasma insulin levels in female Wistar fatty rats.
  • Reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice.

Catalog No. 50-004-32989


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