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Cayman Chemical AloIsolIthocholIc AcId-d4 5mg
SDP

Supplier:  Cayman Chemical 411555 MG

Encompass_Preferred

A PDE4D negative allosteric modulator (IC50 28 nM for the human enzyme) selective for PDE4D over PDE4B (IC50 562 nM for the human enzyme) as well as 14 other PDE isoforms (IC50s 1.4 UM) decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 253 nM) and dextran gel-induced increases in leukotriene E4 production in isolated human whole blood (IC50 44 nM) impairs novel object recognition in mice at 3 mg/kg but does not increase anesthesia duration a proxy measure of emesis induction in mice at 3 or 10 mg/kg

Catalog No. 50-294-4780


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