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Cayman Chemical AlosetronhydrochlorIde 100mg
Supplier: Cayman Chemical 22434100 MG
A 5-HT3 receptor antagonist (Kis = 0.3 and 0.4 nM for the rat cortical and human recombinant receptors, respectively); selective for 5-HT3 over 5-HT2 and 5-HT1A receptors (Kis = 6.3 and >100 µM, respectively), as well as α1-, β1-, and β2- adrenergic, M1, M2, and M3 muscarinic, GABAA, dopamine D2, and nicotinic receptors at 10 μM; inhibits 5-HT-induced depolarization of isolated rat vagus nerve at 0.3-10 nM; reduces wrap restraint stress-induced defecation and the number of abdominal muscle contractions in a rat model of IBS-D at 0.1 mg/kg
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