Medchemexpress LLC Alpelisib | 1217486-61-7 | C19H23ClF3N5O2S | 5 MG

Supplier:  Medchemexpress LLC HY15244A5MG

Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM for p110α. It exhibits antineoplastic activity and potently inhibits Akt phosphorylation in cells transformed with PI3Kα.

• Potently inhibits PIK3CA somatic mutations (H1047R, E545K; IC50s~4 nM).
• Significantly reduces Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM).
• Inhibits cell growth of osteosarcoma cell lines.
• Induces G0/G1 phase cell cycle arrest in human and murine osteosarcoma cells.
• Reduces tumor volumes and deposition of ectopic bone matrix in animal models.
• Store powder at -20°C for 3 years or 4°C for 2 years.
• Store in solvent at -80°C for 2 years or -20°C for 1 year.
• Shipping can occur at room temperature if duration is less than 2 weeks.

Catalog No. 50-003-73658