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Medchemexpress LLC Alpelisib hydrochloride | 1584128-91-5 | 50 MG
Supplier: Medchemexpress LLC HY15244A50MG
Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor, demonstrating antineoplastic activity. It effectively inhibits the two most prevalent PIK3CA somatic mutations, H1047R and E545K, and suppresses Akt phosphorylation in cells. This compound has shown to inhibit the growth of osteosarcoma cell lines and induce cell cycle arrest in the G0/G1 phase.
- Potent, orally active, and selective PI3Kα inhibitor
- Exhibits antineoplastic activity
- Effectively inhibits PIK3CA somatic mutations H1047R and E545K
- Suppresses Akt phosphorylation in cells
- Inhibits cell growth of osteosarcoma cell lines
- Induces cell cycle arrest in G0/G1 phase
- Significantly reduces tumor volumes in vivo
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