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Medchemexpress LLC Alpelisib (hydrochloride) | 1584128-91-5 | C19H23ClF3N5O2S | 100 MG
Supplier: Medchemexpress LLC HY15244A100MG
Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with demonstrated antineoplastic activity. It potently inhibits Akt phosphorylation in cells transformed with PI3Kα and also exhibits reduced inhibitory activity in PI3Kβ or PI3Kδ isoforms transformed cells.
- Potently inhibits common PIK3CA somatic mutations (H1047R, E545K)
- Significantly reduces tumor volumes and ectopic bone matrix deposition in vivo
- Induces cell cycle arrest in the G0/G1 phase of human and murine osteosarcoma cell lines
- Used in various clinical trials for diverse conditions and phases
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