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Medchemexpress LLC Alpha-Estradiol | 57-91-0 | 99.9% | 5 G
Supplier: Medchemexpress LLC HYB0141A5G
Alpha-Estradiol is identified as a weak estrogen and a 5α-reductase inhibitor. It is employed as a topical medication for treating androgenic alopecia.
- Weak estrogen.
- Acts as a 5α-reductase inhibitor, preventing testosterone metabolism catalyzed by 5 alpha-reductase.
- Attenuates LPS-induced inflammatory markers in mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes, and differentiated 3T3-L1 adipocytes through an ERα-dependent mechanism.
- Decreases NFκB-p65 and elevates ERα protein expression.
- Significantly reduces the central avascular/total retina area in mouse pups.
- Lowers malondialdehyde (MDA) levels, the number of NADPH-oxidase-positive cells, NADPH oxidase concentration, and activity in the retinas of hyperoxia-exposed pups.
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