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ABclonal Technology ALPK1 Rabbit mAb
Supplier: ABclonal Technology A24046100UL
- Protein Kinase 1 also known as - ALPK1 is associated with chronic kidney disease (CKD) myocardial infarction gout and type 2 diabetes According to reports ALPK1 mutations can lead to serious deficits in motor coordination in mice ALPK1 can enhance the expression of pro-inflammatory cytokines including IL-1 in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID 31557402 PMID 26275947) IL-8 and TGF- 1 The ALPK1 short subtype (108 kDa) is highly expressed in the brain spinal cord heart lungs spleen thymus small intestine skin and testes while detecting skeletal muscle and kidney ALPK1 isoform (130 kDa) appears in the heart lungs thymus and skin As a novel innate immune receptor ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed 30111836 PubMed 30111836)
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