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Cayman Chemical ALT asy Cofactr 1ea
Supplier: Cayman Chemical 7002631 EA
A Cdk9 inhibitor (IC50 6 nM) selective for Cdk9 over Cdk1-8 (IC50s 397->10000 nM) and Cdk12-19 (IC50s 372->10000 nM) induces cell cycle arrest at the G1 phase and apoptosis in BT-20 BT-549 MDA-MB-231 MT-3 and Hs 578T TNBC cells from 0.64-7.73 UM reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg
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