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AdipoGen Alternariol
SDP

Supplier:  AdipoGen BVT0465M005

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Chemical. CAS 641-38-3. Formula C14H10O5. MW 258.2. Isolated from Alternaria sp. Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks SSB and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor sub-µM IC50 values. Antiviral activity herpes simplex. Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.

Catalog No. 50-256-1895


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