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Apexbio Technology LLC Altiratinib 1345847-93-9 10mg
Supplier: Apexbio Technology LLC B583210
Altiratinib (DCC-2701 CAS 1345847-93-9) is a multi-targeted small molecule inhibitor designed to block the activity of the receptor tyrosine kinases c-MET TIE-2 and VEGFR It demonstrates potent inhibitory activity with reported IC50 values of 2 7 nM for c-MET 8 0 nM for TIE-2 and 9 2 nM for VEGFR In cell-based assays Altiratinib suppresses phosphorylation of MET in MET-overexpressing EBC-1 and MKN-45 cell lines and inhibits TIE2 and VEGFR2 activation in endothelial models In preclinical xenograft studies Altiratinib reduces MET phosphorylation and tumor burden This compound is utilized to investigate pathways involved in tumor growth angiogenesis and microenvironment-mediated drug resistance
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