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Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 10 MG
SDP

Catalog No. 5000365079
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Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62±29 nM.

  • Potent inhibitor of Hsp90.
  • Inhibits the growth of human cancer cell lines SKBR3 and SKOV3.
  • Causes down-regulation of Her2 and induction of Hsp70 in SKBR3 and SKOV3 cells.
  • Exerts dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells at concentrations of 50nM to 500nM.
  • Demonstrates time-dependent apoptosis in CLL cells with extended exposure from 24 to 48 hours.
  • More potent than 17-AAG after 24 and 48 hours of treatment in CLL cells.
  • Significantly reduces tumor volumes in an animal model of gastrointestinal cancer when administered at 10 or 20 mg/kg.

Catalog No. 50-003-65079 Supplier Medchemexpress LLC Supplier No. 10MGHY12024
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Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62±29 nM.

  • Potent inhibitor of Hsp90.
  • Inhibits the growth of human cancer cell lines SKBR3 and SKOV3.
  • Causes down-regulation of Her2 and induction of Hsp70 in SKBR3 and SKOV3 cells.
  • Exerts dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells at concentrations of 50nM to 500nM.
  • Demonstrates time-dependent apoptosis in CLL cells with extended exposure from 24 to 48 hours.
  • More potent than 17-AAG after 24 and 48 hours of treatment in CLL cells.
  • Significantly reduces tumor volumes in an animal model of gastrointestinal cancer when administered at 10 or 20 mg/kg.

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