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Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 200 MG
Supplier: Medchemexpress LLC 200MGHY12024
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. It inhibits the growth of human cancer cell lines SKBR3 and SKOV3, which overexpress Hsp90 client protein Her2, leading to down-regulation of Her2 and induction of Hsp70. It also induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells.
- Potent inhibitor of Hsp90
- Binds to Hsp90 with an EC50 of 62 ± 29 nM
- Inhibits the growth of human cancer cell lines SKBR3 and SKOV3
- Causes down-regulation of Her2
- Induces Hsp70
- Induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells
- Significant reduction in tumor size in animal models
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