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Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g·mol⁻¹ | C34H49F3N4O10 | 25 MG
Supplier: Medchemexpress LLC HY10389A25MG
Alvespimycin trifluoroacetate (17-DMAG TFA) is the trifluoroacetic acid salt of a semisynthetic geldanamycin derivative that potently inhibits Hsp90. It binds Hsp90 in the low-nanomolar range and is used in cellular and biochemical studies to induce heat-shock response and promote degradation of Hsp90 client proteins, supporting research into proteostasis and targeted oncology pathways.
- Potent Hsp90 inhibition with reported EC50 ≈ 62 nM.
- Promotes Her2 degradation in cancer cell lines (EC50 8 nM in SKBR3, 46 nM in SKOV3).
- Induces Hsp70 expression in cell assays (EC50 4 nM in SKBR3, 14 nM in SKOV3).
- High purity (>98.9%) suitable for in vitro studies.
- Available in small research pack sizes, including 25 MG.
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