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Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg
Supplier: Apexbio Technology LLC A3167200
AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes
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