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Medchemexpress LLC AM-5308 | 2410796-89-1 | 99.15% | C26H35N5O5S | 1 ML
Supplier: Medchemexpress LLC HY14489410MM/1ML
AM-5308 is an inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. It activates mitotic checkpoints, regulates cell division processes including chromosome segregation and spindle assembly, and exhibits antitumor activity.
- Inhibits KIF18A-mediated microtubule ATPase activity
- Activates mitotic checkpoints
- Regulates cell division processes, including chromosome segregation and spindle assembly
- Exhibits antitumor activity
- Exhibits cytotoxicity in human bone marrow cells
- Arrests the cell cycle of MDA-MB-157 and human bone marrow cells in the mitosis phase
- Inhibits tumor growth in mouse OVCAR-3 xenograft models
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