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Medchemexpress LLC AM-5308 | 2410796-89-1 | 99.2% | C26H35N5O5S | 50 MG

Supplier: Medchemexpress LLC HY14489450MG
AM-5308 is an inhibitor for KIF18A that inhibits KIF18A-mediated microtubule ATPase activity. It activates mitotic checkpoints, regulates cell division processes, and exhibits antitumor activity.
- Inhibits KIF18A-mediated microtubule ATPase activity
- Activates mitotic checkpoints
- Regulates cell division processes, including chromosome segregation and spindle assembly
- Exhibits antitumor activity
- Shows cytotoxicity in human bone marrow cells in vitro
- Arrests cell cycle of MDA-MB-157 and human bone marrow cells in mitosis phase in vitro
- Demonstrates antitumor activity in mouse OVCAR-3 xenograft models in vivo
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