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Medchemexpress LLC AM095 free acid | 1228690-36-5 | 99.0% | 456.49 | 200 MG
Supplier: Medchemexpress LLC HY16040200MG
AM095 free acid is a potent LPA1 receptor antagonist that effectively inhibits LPA-induced calcium flux in CHO cells transfected with human or mouse LPA1. It also significantly reduces LPA-induced vasorelaxation and inhibits LPA-driven chemotaxis in various cell types. In preclinical studies, it has shown to attenuate bleomycin-induced dermal fibrosis and decrease kidney fibrosis in a mouse model of unilateral ureteral obstruction. The compound exhibits high oral bioavailability, a moderate half-life, and is well tolerated in animal models.
- Potent LPA1 receptor antagonist.
- Inhibits LPA-induced calcium flux in CHO cells.
- Reduces LPA-induced vasorelaxation.
- Inhibits LPA-driven chemotaxis in melanoma cells.
- Attenuates bleomycin-induced dermal fibrosis in vivo.
- Decreases kidney fibrosis in a mouse model.
- High oral bioavailability.
- Moderate half-life.
- Well tolerated in rats and dogs.
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