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Cayman Chemical AM92016hydrochlorIde 10mg
Supplier: Cayman Chemical 3680310 MG
An IKr inhibitor (IC50 = 40 nM in isolated rabbit sinoatrial node cells); selective for IKr over L-type Cav current and If at 1 µM; decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells at 50 nM; decreases the QT interval and increases heart rate in anesthetized guinea pigs at 1 mg/kg; decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs at 1 mg/kg
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