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Medchemexpress LLC Amantadine hydrochloride | 665-66-7 | 98.0% | 10 G
Supplier: Medchemexpress LLC HYB0402A10G
Amantadine hydrochloride is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA and M2, and also targets Coronavirus ion channels. This compound also demonstrates anti-orthopoxvirus and anticancer activities, making it suitable for research in Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Inhibits SARS-CoV-2 replication
- Inhibits proliferation of HepG2 and SMMC-7721 cells
- Arrests cell cycle at G0/G1 phase and induces apoptosis
- Reduces levels of cell cycle-related genes and proteins
- Reduces Bcl-2 and increases Bax protein and mRNA levels
- Inhibits surgery-induced neuroinflammation and learning and memory impairment
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