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AdipoGen Amastatin hydrochloride
Supplier: AdipoGen AGCP37003M005
Chemical. CAS 100938-10-1. Formula C21H38N4O8 . HCl. MW 474.6 . 36.5. Synthetic. Slow, tight binding and competitive aminopeptidase AP inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A AP-A, aminopeptidase N AP-N, tyrosine aminopeptidase, but not aminopeptidase B AP-B. Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin or thermolysin. Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III Ang III from Angiotensin II through AP-A, but significantly increases the potency of angiotensin III and-angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase MIP. Weak inhibitor of simian immunodeficiency virus protease SIV-PR.
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