Mixed-mode stationary phase combining reversed-phase with strong anion-exchange and cation-exclusion functionality. Provides retention for hydrophobic drugs, acidic counter-ions, weakly acidic compounds, and basic polymers. Suitable for applications requiring strong anion-exchange selectivity in combination with reversed-phase retention. Single-ligand design with a surface-proximal basic group (pKa ~10) that shields residual silanols and reduces secondary interactions.Provides ion-pairing functionality on the stationary phase, maintaining full MS compatibility without ion-pairing reagents in the mobile phase. Provides comparable selectivity and retention to established mixed-mode stationary phases, enabling direct method transfer with minimal adjustment.