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Medchemexpress LLC AMG 333 | 1416799-28-4 | 99.8% | 453.32 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11270310MM/1ML

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AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. It is for research use only, not for sale to patients.

  • Orally active and highly selective TRPM8 antagonist
  • IC50 of 13 nM (TRPM8)
  • Inhibits wet-dog shake behavior in Icilin-induced Sprague-Dawley rat model
  • Blocks blood pressure elevation in cold stimulation-induced Sprague-Dawley rat model
  • Effectively blocks the TRPM8 target
  • Demonstrates significant dose-dependent inhibition of wet-dog shake behavior
  • Shows significant inhibition of cold-induced blood pressure elevation
  • Potential clinical candidate for the treatment of migraine

Catalog No. 50-004-38543


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