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Medchemexpress LLC AMG 333 | 1416799-28-4 | 99.8% | 453.32 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY112703

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AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. It dose-dependently inhibits wet-dog shake behavior and blocks blood pressure elevation in rat models, making it a clinical candidate for the treatment of migraine.

  • Orally active and highly selective TRPM8 antagonist
  • Dose-dependently inhibits wet-dog shake behavior in the Icilin-induced wet-dog shake Sprague-Dawley rat model
  • Dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague-Dawley rat model
  • A clinical candidate for the treatment of migraine

Catalog No. 50-004-39658


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