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Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
Supplier: Medchemexpress LLC HY15319100MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
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