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Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.86% | 534.48 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108642B
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor, showing slight selectivity over p38β and >1000-fold selectivity against p38γ and p38δ. It is also extremely potent in inhibiting whole blood LPS stimulated TNFα and inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Orally active and selective p38α inhibitor.
- Exhibits potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Modest selectivity against JNK2 (ki=39 nM) and JNK3 (ki=61 nM).
- Rat F of 62% and dog F of 47%.
- t1/2 is 4.6 hours in rats and 7.3 hours in dogs.
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